Applications of high-frequency ultrasound microscopy in medicine and biology
نویسنده
چکیده
In this chapter, the applications of high-frequency ultrasound microscopy are reviewed. Several popular types of acoustic microscopy are included, such as scanning acoustic microscopy, ultrasound backscatter microscopy, atomic force acoustic microscopy, and resonance ultrasound microscopy. The working principle and system diagram (both hardware and signal processing) are introduced first. Currently, there are plenty of their applications in medicine and biology, such as enzymatically induced degradation of articular cartilage, three-dimensional characterization of human skin, melanoma progression, infarcted myocardium, early-stage mouse embryos, heart muscle cells, intracellular changes, and cell apoptosis. The technological development of various acoustic microscopies in the past decades is described, and their advantages and limitations are compared. The future development of this device in both technical and application aspects is discussed for both researchers and users.
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